Hegesippus of Mecyberna was a Greek historian of the 4th century BCE. He was a native of the coastal town of Mecyberna in Chalcidice, which served as the harbor for Olynthus. His work indicates he was active during the reign of Philip II of Macedon and was likely a contemporary of the Macedonian expansion, including the destruction of Olynthus in 348 BCE.

His sole known work is a history, possibly titled On Macedonia, which survives only in fragments cited by later authors like Harpocration and Stephanus of Byzantium. These fragments indicate it covered events related to Philip II and the history of the Chalcidice region.

Hegesippus is a minor historian whose significance lies in being a local source for the history of Chalcidice and the rise of Macedon. His fragments provide valuable evidence for regional history and toponyms, making his work one of the earliest histories focused on Macedonian affairs, though it did not survive into the Middle Ages.