Asclepiades of Myrlea was a Greek grammarian and historian who lived and worked in the 1st century BCE. He was born in Myrlea, later called Apamea, in the region of Bithynia in northwestern Turkey. He studied under the grammarian Apollodorus of Athens and later moved to Rome to teach, where he was a contemporary of the Roman scholar Varro.

Asclepiades specialized in grammar, history, and mythology. None of his works survive intact; they are known only through fragments and references by later ancient authors. His lost writings include a work On Grammar, a historical study On the History of Etruria, a History of Bithynia, and texts on mythology and specific grammatical topics.

Modern scholars regard Asclepiades as a significant figure in the transfer of Greek learning to Rome. His teachings are thought to have influenced Roman intellectuals like Varro, who helped systematize the study of the Latin language. His historical writings were used as sources by later geographers like Strabo, indicating his works were considered authoritative. His career exemplifies the movement of Greek scholars to Rome, which played a key role in the development of Greco-Roman culture.