Sophron was a fifth-century BCE writer of mimes from Syracuse in Sicily, a contemporary of the tragedian Euripides. Little is known of his personal life, but he was the father of Xenarchus, who also wrote mimes. He composed his works in the local Doric dialect.

His works survive only in fragments, primarily under the titles Mimes of Men and Mimes of Women. These were prose compositions, possibly rhythmic, depicting realistic scenes from daily life. Surviving fragments portray a range of characters and scenarios, such as a mother scolding her daughter or a fisherman boasting about his catch.

Sophron is a significant pioneer of the literary mime genre. His realistic sketches were highly regarded in antiquity; Plato reportedly admired him and introduced his work to Athens. This admiration indicates Sophron's influence on later comic and character-driven literature. His use of the Doric dialect and Sicilian setting provides valuable insight into the language and social milieu of fifth-century Syracuse.