Patrocles of Thurii was a 4th-century BCE comic playwright from the panhellenic colony of Thurii in Magna Graecia. His floruit places him within the era of Middle Comedy. As a non-Athenian poet, he likely traveled to Athens to compete at dramatic festivals like the Dionysia, though no further biographical details are recorded.

A single comedy, Dionysos, is attributed to him. The play is lost, surviving only by title and in a one-line fragment preserved by the grammarian Athenaeus. Patrocles is a minor figure, known only from a single citation in the Suda. His significance lies as a data point demonstrating the geographical spread of comic poets and the participation of non-Athenians in Athenian theatrical culture. The title Dionysos suggests a thematic connection to the god of the festival, but the extant fragment is too scant for further analysis.