Metrodorus of Scepsis was a Greek historian and philosopher from Scepsis in the Troad who lived during the 2nd and 1st centuries BCE. He was a close friend and courtier to King Mithridates VI of Pontus. The king held him in such high esteem that he called him "father" and entrusted him with diplomatic missions, including an embassy to King Tigranes of Armenia.

Metrodorus died by poison. The geographer Strabo attributes this murder to Tigranes, while the Byzantine encyclopedia Suda claims Mithridates ordered it after a falling out. His only securely attested work is the lost treatise On Tactics, mentioned by the Suda. The same source dubiously attributes a work titled Troica to him, which may refer to a different author.

Metrodorus is significant for providing a lost Pontic perspective on the Mithridatic Wars against Rome. His political role exemplifies the integration of Greek intellectuals as advisors and diplomats in Hellenistic courts. The conflicting accounts of his death underscore the perilous nature of contemporary court politics.