John of Epiphania was a late 6th-century Byzantine historian from Epiphania in Syria. He served as the legal assessor to Gregory, Patriarch of Antioch, a high office that involved him directly in major political events. In 589 CE, he accompanied Gregory to Constantinople and was later entrusted with a mission to escort the fleeing Persian shah, Khosrow II, to the Byzantine capital, giving him eyewitness knowledge of critical diplomatic affairs.

His sole known work is a History, which covered the aftermath of the Roman-Persian war of 572–591 CE and the early reign of Emperor Maurice. This text is now lost except for a substantial fragment preserved in the Bibliotheca of the 9th-century patriarch Photius.

John is a significant, though fragmentary, source for late 6th-century Byzantine-Persian relations. His work was used by later historians like Theophylact Simocatta, and Photius praised his clear and dignified classical style. As an involved official, his history is valued for its eyewitness authority on the diplomacy between the Byzantine and Sassanian Empires.