Creophylus of Ephesus is identified in certain metadata as a 4th-century BCE historian from Ephesus, but this figure is unattested in standard scholarly references. The name Creophylus is instead associated with Creophylus of Samos, a legendary early epic poet traditionally linked to the Homeric cycle.

No historical work by a Creophylus of Ephesus is recorded. The only literary work connected to the name Creophylus is the lost epic poem The Capture of Oechalia, attributed to Creophylus of Samos.

The significance of Creophylus of Ephesus as a historian cannot be established due to a lack of evidence. The name holds importance only in the context of early epic poetry, pertaining solely to the legendary poet from Samos.