Asclepiades of Mendes was a grammarian from the Egyptian city of Mendes, active during the 1st century BCE. No further biographical details of his life are preserved.

His sole attested work is the lost treatise On the Grammar of Democritus, which analyzed the language of the pre-Socratic philosopher Democritus. Asclepiades is a minor but clear example of a specific Hellenistic scholarly genre: specialized grammatical studies of individual classical authors. His work’s mention in later sources like the Suda places him within the tradition of Alexandrian scholarship focused on textual and linguistic analysis.