Alexis of Samos was a Hellenistic historian of the 3rd century BCE. No details of his personal life survive. He lived during the era of the Diadochi, when local historians often documented their own regions.

His sole known work is the Samiaka, a history of Samos. The work is lost, surviving only in fragments preserved primarily by Athenaeus of Naucratis in his Deipnosophistae. Alexis is a significant source for Samian local history and antiquities. His fragments, cited by later authors, preserve details on Samian customs, historical anecdotes, and figures, such as the pirate Hegesagoras. His work exemplifies the Hellenistic genre of local historiography that preserved regional traditions.