Sophilus was an Athenian comic poet of the 4th century BCE and a contemporary of the orator Demosthenes. According to the 10th-century Byzantine encyclopedia, the Suda, he wrote seven plays and was victorious once in competition. The ancient scholar Athenaeus refers to him as a poet of Middle Comedy, the period from roughly 400 to 320 BCE.

Only two of his play titles are known: The Marriage, from which a single fragment concerning a food item survives, and The Tyrrhenian. All his works are lost except for such brief citations.

Sophilus is a minor figure, but his work confirms him as a practitioner of Middle Comedy, the transitional phase between Old and New Comedy. The title The Tyrrhenian suggests an engagement with non-Greek cultures, a known interest in the period. His surviving fragment is typical of Middle Comedy remnants preserved in Athenaeus’s dining-focused Deipnosophistae.