Nicander of Colophon II was a Hellenistic prose writer of the 2nd century BCE, distinguished from the more famous poet of the same name. The geographer Strabo identifies him as a writer from Colophon in Asia Minor. No further biographical details survive.

His only known work is the lost local history titled Colophoniaca. No fragments or specific content from this work are preserved.

His primary significance lies in his distinction from the poet Nicander. He represents the common Hellenistic tradition of local historiography, and his work, though lost, served as a source for later authors like Strabo.