Aristomenes of Alyzeia was a Greek comic poet of the 3rd century BCE from Alyzeia in Acarnania. The Suda identifies him as a contemporary of Alexis and Amphis, notes his competition at Athenian festivals, and records a victory at the Lenaea. His floruit places him in the transitional period from Middle to New Comedy.

Two comedies are attributed to him: Admetus and The Pipe-Player. Athenaeus credits him with a third, The Titans. All are lost, surviving only in fragments and titles, such as a mention of a pastry preserved by Athenaeus.

Aristomenes is a minor figure whose significance lies in his chronological position. He represents the later evolution of comedy, as the genre shifted from mythological satire toward the domestic plots of New Comedy. His scant fragments contribute to the understanding of the largely lost corpus of Middle Comedy.